Τίτλος:
COVID-19 and post-traumatic stress disorder: The perfect `storm' for
mental health (Review)
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Since its outbreak, in December, 2019, in the Chinese city of Wuhan,
coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has evolved into an ongoing global
pandemic. Due to the novel antigenic properties of this virus, the world
population could not develop immunity effectively and this led to the
subsequent spread of COVID-19. This caused an unprecedented emergency
situation with significant negative effects on health and well-being
both on an individual and societal level. Apart from health, economic
and social consequences, the impact of this pandemic on mental health is
increasingly being reported in the scientific literature. The present
review aimed to provide a comprehensive discussion of the possible
neurological and neuropsychiatric manifestations of SARS-CoV-2, together
with the related underlying molecular pathways. In addition, the present
review focused on populations which are at a higher risk of developing
psychiatric disturbances due to the COVID-19 pandemic and discussed
possible routes of clinical management and therapeutics to minimize the
burden associated with psychiatric disorders. Moreover, research
findings exploring the prevalence of COVID-19-related post-traumatic
stress disorder (PTSD) symptoms across vulnerable groups, including
children, adolescents and COVID-19 survivors are presented, with
particular emphasis on those with severe disease who required
hospitalization and/or intensive care unit admission. Based on the
available literature, the identification of potential determinants
associated with PTSD across the different populations is underlined.
Lessons learnt from the pandemics across the globe together with the
ongoing research on COVID-19 and its impact on mental health, highlight
the utmost importance for evidence-based, proactive and targeted
interventions in high-risk groups aiming to mitigate the risks and
manage vulnerabilities.
Συγγραφείς:
Giannopoulou, Ioanna
Galinaki, Sofia
Kollintza, Evangelia and
Adamaki, Maria
Kympouropoulos, Stylianos
Alevyzakis, Evangelos
and Tsamakis, Konstantinos
Tsangaris, Iraklis
Spandidos,
Demetrios
Siafakas, Nikolaos
Zoumpourlis, Vassilios
Rizos,
Emmanouil
Περιοδικό:
Experimental and Therapeutic Medicine
Εκδότης:
SPANDIDOS PUBL LTD
Λέξεις-κλειδιά:
COVID-19; SARS-CoV-2 neurobiology; mental health; post-traumatic stress
disorder; trauma
DOI:
10.3892/etm.2021.10596
