Περίληψη:
Pregnane X Receptor (PXR) is involved in human cancer, either by
directly affecting carcinogenesis or by inducing drug-drug interactions
and chemotherapy resistance. The clinical significance of PXR expression
in invasive breast carcinoma was evaluated in the present study. PXR
protein expression was assessed immunohistochemically on formalin fixed
paraffin-embedded breast invasive carcinoma tissue sections, obtained
from 148 patients, and was correlated with clinicopathological
parameters, molecular phenotypes, tumor cells’ proliferative capacity,
and overall disease-free patients’ survival. Additionally, the
expression of PXR was examined on human breast carcinoma cell lines of
different histological grade, hormonal status, and metastatic potential.
PXR positivity was noted in 79 (53.4%) and high PXR expression in 48
(32.4%), out of 148 breast carcinoma cases. High PXR expression was
positively associated with nuclear grade (p = 0.0112) and histological
grade of differentiation (p = 0.0305), as well as with tumor cells’
proliferative capacity (p = 0.0051), and negatively with luminal A
subtype (p = 0.0295). Associations between high PXR expression,
estrogen, and progesterone receptor negative status were also recorded
(p = 0.0314 and p = 0.0208, respectively). High PXR expression was
associated with shorter overall patients’ survival times (log-rank test,
p = 0.0009). In multivariate analysis, high PXR expression was
identified as an independent prognostic factor of overall patients’
survival (Cox-regression analysis, p = 0.0082). PXR expression
alterations were also noted in breast cancer cell lines of different
hormonal status. The present data supported evidence that PXR was
related to a more aggressive invasive breast carcinoma phenotype, being
a strong and independent poor prognosticator.
Συγγραφείς:
Theocharis, Stamatios
Giaginis, Constantinos
Gourzi, Stefania
and Alexandrou, Paraskevi
Tsourouflis, Gerasimos
Sarantis,
Panagiotis
Danas, Eugene
Michail, Artemis
Tsoukalas,
Nikolaos
Pergaris, Alexandros
Politis, Panagiotis K. and
Nakopoulou, Lydia
