Τίτλος:
A SAGE score cutoff that predicts high-pulse wave velocity as measured
by oscillometric devices in Brazilian hypertensive patients
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
We aimed to identify the optimal cutoff SAGE score for Brazilian
hypertensive patients who had their pulse wave velocity (PWV) measured
with oscillometric devices. A retrospective analysis of patients who
underwent central blood pressure measurement using a validated
oscillometric device, the Mobil-O-Graph (R) (IEM, Stolberg, Germany),
between 2012 and 2019 was performed. Patients with arterial hypertension
and available data on all SAGE parameters were selected. An ROC curve
was constructed using the Youden index to define the best score to
identify patients at high risk for high PWV. A total of 837 patients met
the criteria for SAGE and diagnosis of hypertension. The median age was
59.0 years (interquartile range [IQR]: 47.0-68.0), and 50.7% of the
patients were women. The following comorbidities and conditions were
present: dyslipidemia (37.4%), diabetes (20.7%), a body mass index
score >= 30 kg/m(2) (36.6%), use of antihypertensive drugs (69.5%),
and smoking (18.3%). The median peripheral blood pressure was 128 mmHg
(IQR: 117-138 mmHg) for systolic and 81 mmHg (IQR: 73-90 mmHg) for
diastolic blood pressure. The median PWV was 8.3 m/s (7.1-9.8 m/s), and
the prevalence of high PWV (>= 10 m/s) was 22.9% (192 patients). A
cutoff SAGE score >= 8 was effective at identifying a high risk of PWV
>= 10 m/s, achieving 67.19% sensitivity (95% CI: 60.1-73.8) and
93.95% specificity (95% CI: 91.8-95.7). With this cutoff point, 1 out
of every 5 treated hypertensive patients would be referred for a PWV
measurement. A SAGE score of >= 8 identified Brazilian hypertensive
patients with a high risk of future cardiovascular events (PWV >= 10
m/s).
Συγγραφείς:
Oliveira, Adriana Camargo
Sebba Barroso, Weimar Kunz
de Oliveira
Vitorino, Priscila Valverde
Lima Sousa, Ana Luiza
Fagundes,
Rayne Ramos
de Deus, Gilcimar Divino
Guimaraes, Gilberto Campos
and Barbosa, Eduardo
Xaplanteris, Panagiotis
Vlachopoulos,
Charalambos
Περιοδικό:
Hypertension Research
Λέξεις-κλειδιά:
Arterial stiffness; Hypertension; Risk factors; Risk scores; Triage
DOI:
10.1038/s41440-021-00793-0
