Τίτλος:
Non-surgical treatment of hilar cholangiocarcinoma
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Cancer of the biliary confluence also known as hilar cholangiocarcinoma
(HC) or Klatskin tumor, is a rare type of neoplastic disease
constituting approximately 40%-60% of intrahepatic malignancies, and
2% of all cancers. The prognosis is extremely poor and the majority of
Klatskin tumors are deemed unresectable upon diagnosis. Most patients
with unresectable bile duct cancer die within the first year after
diagnosis, due to hepatic failure, and/or infectious complications
secondary to biliary obstruction. Curative treatments include surgical
resection and liver transplantation in highly selected patients.
Nevertheless, very few patients are eligible for surgery or transplant
at the time of diagnosis. For patients with unresectable HC,
radiotherapy, chemotherapy, photodynamic therapy, and liver-directed
minimally invasive procedures such as percutaneous image-guided ablation
and intra-arterial chemoembolization are recommended treatment options.
This review focuses on currently available treatment options for
unresectable HC and discusses future perspectives that could optimize
outcomes.
Συγγραφείς:
Inchingolo, Riccardo
Acquafredda, Fabrizio
Ferraro, Valentina
and Laera, Letizia
Surico, Gianmarco
Surgo, Alessia and
Fiorentino, Alba
Marini, Stefania
de'Angelis, Nicola
Memeo,
Riccardo
Spiliopoulos, Stavros
Περιοδικό:
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
Εκδότης:
BAISHIDENG PUBLISHING GROUP INC
Λέξεις-κλειδιά:
Cholangiocarcinoma; Interventional radiology; Oncology; Liver;
Radiotherapy; Ablation
DOI:
10.4251/wjgo.v13.i11.1696
