Τίτλος:
The role of 18F-FDG PET/CT scan compared to CT-scan alone for lymph node
staging before radical cystectomy in patients with bladder cancer
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Accurate Lymph node (LN) staging before radical cystectomy
(RC) in patients with bladder cancer (BC) is crucial to improve
patient’s management. 18F-fluorodeoxyglucose positron-emission
tomography-computed tomography (FDG-PET-CT) become widely used in the
loco-regional staging of BC. The diagnostic performance of PET-CT in
preoperative LN staging of BC is still unknown due to lacking large
trials.
Objectives: We aim to evaluate the diagnostic value of PET-CT scan,
compared with CT scan alone for preoperative LN staging of BC.
Patients and methods: From January 2010 to November 2020, we
retrospectively reviewed the records of 300 patients undergoing RC for
muscle-invasive BC and high-risk non-muscle-invasive BC. All patients
had PET-CT and CT of abdomen and pelvis to assess for pelvic LN
metastases before RC. Patients were excluded from analysis if they had
neoadjuvant chemotherapy (NAC). Sensitivity, specificity, and accuracy
for detecting pelvic LN metastases were determined by comparing the
results of the FDG PET-CT and CT alone to the final histopathology
reports obtained after RC.
Results: LN metastasis was confirmed histology in 134 patients (44.7%).
On a patient-based analysis, PET-CT, and CT showed a sensitivity of
40.3% and 13.4 %, respectively, a specificity of 79.5% and 86.7 %,
respectively, positive predictive value (PPV) of 61.4% and 45%,
respectively, and negative predictive value (NPV) of 62.3% and 55.4%,
respectively. The diagnostic accuracy of PET-CT scan depends on multiple
preoperative and postoperative factors.
Conclusion: PET-CT is more accurate than CT-scan alone for preoperative
LN staging in patients with BC. (C) 2021 Elsevier Inc. All rights
reserved.
Συγγραφείς:
Moussa, Mohamad
Abou Chakra, Mohamad
Saad, Wajih
Dellis,
Athanasios
Papatsoris, Athanasios
Περιοδικό:
Urologic Oncology: Seminars and Original Investigations
Εκδότης:
EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
Λέξεις-κλειδιά:
18F-fluorodeoxyglucose positron emission tomography-computed tomography;
Bladder cancer; Radical cystectomy; Computed tomography; Pelvic lymph
node
DOI:
10.1016/j.urolonc.2021.04.027
