Τίτλος:
Low Admission Immunoglobulin G Levels Predict Poor Outcome in Patients
with Mild-to-Critical COVID-19: A Prospective, Single-Center Study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Introduction Immunoglobulins (Igs) comprise a critical part of the
immune response. Little information exists on Ig serum levels in
COVID-19 patients. We, therefore, investigated whether hospital
admission Igs in patients with mild-to-critical disease are associated
with clinical outcome.
Materials and Methods This prospective, observational, single-center,
cross-sectional study included 126 consecutive noncritically ill and
critically ill and COVID-19 patients, in whom IgG, IgM, and IgA were
measured on hospital admission.
Results The cohort was divided in survivors and non-survivors, based on
in-hospital mortality. Median IgG levels of survivors were significantly
higher than non-survivors (p < 0.01). The cohort was subsequently
divided in IgG deficient (< 690 mg/ dl) and sufficient (>= 690 mg/dl)
patients. IgG-deficient patients had a higher mortality rate (p < 0.01).
The multivariate logistic regression model showed that subnormal IgG was
significantly associated with increased mortality risk (p < 0.01).
Conclusion In our COVID-19 cohort, admission subnormal IgG levels might
be independently associated with reduced survival.
Συγγραφείς:
Vrettou, Charikleia S.
Vassiliou, Alice G.
Kakkas, Ioannis and
Jahaj, Edison
Tsipilis, Stamatios
Athanasiou, Nikolaos and
Zacharis, Alexandros
Keskinidou, Chrysi
Papageorgiou, Aikaterini
and Orfanos, Stylianos E.
Kotanidou, Anastasia
Dimopoulou,
Ioanna
Περιοδικό:
Journal of Epidemiology and Global Health
Λέξεις-κλειδιά:
Immunoglobulin G; COVID-19; Mortality; Intensive care unit
DOI:
10.1007/s44197-021-00002-8
