Περίληψη:
Human papillomavirus 16 (HPV16) infection is the aetiologic factor for
the development of cervical dysplasia and is regarded as highly
carcinogen, because it is implicated in more than 50% of cervical
cancer cases, worldwide. The tumourigenic potential of HPV16 has
triggered the extensive sequence analysis of viral genome in order to
identify nucleotide variations and amino acid substitutions that
influence viral oncogenicity and subsequently the initiation and
progression of cervical cancer. Nowadays, specific mutations of HPV16
DNA have been associated with an increased risk of high-grade squamous
intraepithelial lesions and invasive cervical cancer (ICC) development,
including E6: Q14H, H78Y, L83V, Epsilon 7: N29S, S63F, E2: H35Q, P219S,
T310K, E5: I65V, whereas highly conserved regions of viral DNA have been
extensively characterised. In addition, numerous novel HPV16 mutations
are observed among the studied populations from various geographic
regions, hence advocating that different HPV16 strains seem to emerge
with different tumourigenic capacities. The present review focuses on
the variability of the early genes and the long control region,
emphasising on the association of specific mutations with the
development of severe dysplasia. Finally, it evaluates whether specific
regions of HPV16 DNA are able to serve as valuable biomarkers for
cervical cancer risk.
Συγγραφείς:
Bletsa, G.
Zagouri, F.
Amoutzias, G. D.
Nikolaidis, M. and
Zografos, E.
Markoulatos, P.
Tsakogiannis, D.
