Τίτλος:
The changing epidemiology of hepatocellular carcinoma in Greece
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background Hepatocellular carcinoma (HCC) is the sixth most common
cancer globally, and is attributable mainly to viral hepatitis, alcohol
and nonalcoholic fatty liver disease.
Methods Three hundred Greek patients diagnosed with HCC between 2000 and
2019 were retrospectively evaluated for patient and HCC characteristics.
Patients were classified as before 2011 (A) or after 2011 (B) and HCC
risk factors were compared with historic Greek cohorts.
Results The median age was 64 years and 86% were male; 45% had chronic
hepatitis B virus (HBV) infection, 26% chronic hepatitis C virus (HCV)
infection, and 30% non-viral liver diseases (nvLD). No change was
observed among liver diseases between periods A and B. However, there
was a trend towards a decrease in virally and an increase in non-virally
induced HCC (P=0.075). Patients in period B (vs. A) were more likely to
be diagnosed with fewer (<3, P=0.006) and smaller (<3 cm, P=0.005)
nodules. Compared with 1558 Greek HCC patients from 1974-2000, there was
a decrease in HBV and an increase in HCV and nvLD-related HCCs
(P<0.001).
Conclusions In Greece, after 2000, there was a decrease in the
proportion of HBV and an increase in the proportion of HCV and
nvLD-related HCC, while over the last 2 decades there has been a trend
towards a decrease in virally and an increase in non-virally induced
HCC. Since 2011, HCC is being diagnosed at an earlier stage, possibly
reflecting improved surveillance strategies.
Συγγραφείς:
Markakis, George E.
Koulouris, Andreas
Tampaki, Maria and
Cholongitas, Evangelos
Deutsch, Melanie
Papatheodoridis, George
V.
Koskinas, John
Περιοδικό:
ANNALS OF GASTROENTEROLOGY
Εκδότης:
HELLENIC SOC GASTROENTEROLOGY
Λέξεις-κλειδιά:
Hepatocellular carcinoma; liver; cancer; epidemiology
DOI:
10.20524/aog.2021.0680
