Τίτλος:
Association Between Uric Acid and Worsening Peripheral Microangiopathy
in Systemic Sclerosis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective: The key element in the pathogenesis of systemic sclerosis
(SSc) is microcirculatory changes in several vascular beds. Uric acid is
associated with endothelial dysfunction and therefore, microvascular
damage. The aim of this study was to examine the association between
uric acid (UA) and peripheral microvascular involvement in patients with
SSc.Methods: We included consecutive, consenting patients with SSc.
Serum UA, urea and creatinine were measured, and glomerular filtration
rate (GFR) was calculated with CKD-EPI. All participants underwent
nailfold video-capillaroscopy (NVC) to evaluate the
microcirculation.Results: A total of 64 patients (95.3% women) were
included in the study. UA levels were significantly associated with the
number of avascular areas (r = 0.290; p = 0.020), whereas no correlation
was shown for the GFR (r = -0.065; p = 0.609). A significant trend of UA
in the three capillaroscopic patterns was shown (3.90 +/- 1.52 vs. 4.15
+/- 0.98 vs. 5.38 +/- 2.26; for early, active, and late patterns
respectively, p = 0.028). Multivariate analysis showed that male gender
(beta = 3.049; 95% CI = 0.997-5.101) and UA (beta = 0.352; 95% CI =
0.117-0.588) were independently associated with the number of avascular
areas.Conclusion: These data suggest that UA levels are significantly
associated with the capillaroscopic patterns, reflecting a progressive
microvasculopathy.
Συγγραφείς:
Pagkopoulou, Eleni
Soulaidopoulos, Stergios
Triantafyllidou, Eva
and Malliari, Afrodite
Kitas, George D.
Garyfallos, Alexandros
and Dimitroulas, Theodoros
Περιοδικό:
Frontiers in Cardiovascular Medicine
Εκδότης:
Frontiers Media SA
Λέξεις-κλειδιά:
uric acid; nailfold video-capillaroscopy; microvasculopathy; systemic
sclerosis; cardiovascular
DOI:
10.3389/fmed.2021.806925
