Ερευνητικό υλικό ΕΚΠΑ

Systematic Review and Meta-analysis of Histological Gastric Biopsy
Aspects According to the Updated Sydney System in Children

Αγγλικά

Objectives: A descriptive and comparative study of gastric histological
aspects according to the updated Sydney classification (USC), obtained
from Helicobacter pylori-positive versus H pylori-negative children
referred for upper gastrointestinal endoscopy. Methods: The Prisma
method was used to perform a systematic review and meta-analysis.
Selection criteria were based on following key words USC, H pylori,
children, endoscopy, or biopsy. Publication biases were assessed
according to the Newcastle-Ottawa Scale, and a meta-regression analysis
was done. The study was registered on the PROSPERO platform. Results:
Between 1994 and 2017, 1238 references were found; 97 studies were
retained for the systematic review with a total number of 25,867
children; 75 studies were selected for the meta-analysis concerning 5990
H pylori-infected and 17,782 uninfected children. H pylori-positive
versus H pylori-negative children, according to the USC, showed
significantly higher relative risk for gastric antral and corpus chronic
inflammation, presence of neutrophils, and of lymphoid follicles, and
gastric mucosa atrophy, whereas, intestinal metaplasia showed a
significantly higher RR only in antral biopsies. The meta-regression
analysis showed that H pylori-positive versus H pylori-negative children
had significantly higher risk only for corpus activity according to age,
recurrent abdominal pain, and geographical area of low H pylori
prevalence. Conclusions: H pylori infection in children was associated
with higher relative risk for gastric antral and corpus chronic
inflammation, presence of neutrophils, lymphoid follicles, and rare
gastric mucosa atrophy, whereas, rare intestinal metaplasia was only
significantly higher in the antral area.

2022

Kalach, Nicolas
Zrinjka, Misak
Bontems, Patrick
Kori, Michal
and Homan, Matjaz
Cabral, Jose
Casswall, Thomas
Chong, Sonny
and Cilleruelo, Maria Luz
Faraci, Simona
Megraud, Francis and
Papadopoulou, Alexandra
Pehlivanoglu, Ender
Raymond, Josette and
Rea, Francesca
Maria, Rogalidou
Roma, Eleftheria
Tavares,
Marta
Ugras, Meltem
Urbonas, Vaidotas
Urruzuno, Pedro and
Gosset, Pierre
Creusy, Colette
Delebarre, Mathilde
Verdun,
Stephane
ESPGHAN-Helicobacter Pylori Specia

Journal of Pediatric Gastroenterology and Nutrition,

Lippincott, Williams & Wilkins

74

1

13-19

activity; atrophy; children; gastritis; Helicobacter pylori; intestinal
metaplasia; Sydney classification

https://doi.org/10.1097/MPG.0000000000003259

10.1097/MPG.0000000000003259

https://pergamos.lib.uoa.gr/uoa/dl/object/3033913