Περίληψη:
Cardiovascular disease (CVD) remains the leading cause of death
worldwide, representing a major health, social, and economic issue.
Thyroid disorders are very common and affect >10% of the adult
population in total. The aim of this review is to describe the
physiologic role of thyroid hormones on cardiovascular system, to
present cardiovascular manifestations in patients with thyroid
disorders, emphasizing in molecular mechanisms and biochemical pathways,
and to summarize current knowledge of treatment options. Thyroid hormone
receptors are located both in myocardium and vessels, and changes in
their concentrations affect cardiovascular function. Hyperthyroidism or
hypothyroidism, both clinical and subclinical, without the indicated
therapeutical management, may contribute to the progression of CVD.
According to recent studies, even middle changes in thyroid hormones
levels increase cardiovascular mortality from 20% to 80%. In more
details, thyroid disorders seem to have serious effects on the
cardiovascular system via plenty mechanisms, including dyslipidemia,
hypertension, systolic and diastolic myocardial dysfunction, as well
endothelial dysfunction. On top of clinical thyroid disorders
management, current therapeutics focus on younger patients with
subclinical hypothyroidism and elderly patients with subclinical
hyperthyroidism.
Συγγραφείς:
Paschou, Stavroula A.
Bletsa, Evanthia
Stampouloglou, Panagiota
K.
Tsigkou, Vasiliki
Valatsou, Angeliki
Stefanaki, Katerina
and Kazakou, Paraskevi
Spartalis, Michael
Spartalis, Eleftherios
and Oikonomou, Evangelos
Siasos, Gerasimos
