Τίτλος:
The Role of Ionizing Radiation for Diagnosis and Treatment against
COVID-19: Evidence and Considerations
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The Coronavirus disease 2019 (COVID-19) pandemic continues to spread
worldwide with over 260 million people infected and more than 5 million
deaths, numbers that are escalating on a daily basis. Frontline health
workers and scientists diligently fight to alleviate life-threatening
symptoms and control the spread of the disease. There is an urgent need
for better triage of patients, especially in third world countries, in
order to decrease the pressure induced on healthcare facilities. In the
struggle to treat life-threatening COVID-19 pneumonia, scientists have
debated the clinical use of ionizing radiation (IR). The historical
literature dating back to the 1940s contains many reports of successful
treatment of pneumonia with IR. In this work, we critically review the
literature for the use of IR for both diagnostic and treatment purposes.
We identify details including the computed tomography (CT) scanning
considerations, the radiobiological basis of IR anti-inflammatory
effects, the supportive evidence for low dose radiation therapy (LDRT),
and the risks of radiation-induced cancer and cardiac disease associated
with LDRT. In this paper, we address concerns regarding the effective
management of COVID-19 patients and potential avenues that could provide
empirical evidence for the fight against the disease.
Συγγραφείς:
Chalkia, Marina
Arkoudis, Nikolaos-Achilleas
Maragkoudakis,
Emmanouil
Rallis, Stamatis
Tremi, Ioanna
Georgakilas,
Alexandros G.
Kouloulias, Vassilis
Efstathopoulos, Efstathios
and Platoni, Kalliopi
Περιοδικό:
Cell Stem Cell
Λέξεις-κλειδιά:
ionizing radiation; COVID-19; chest CT; imaging; low dose; radiotherapy;
low dose radiation therapy (LDRT); anti-inflammatory treatment
DOI:
10.3390/cells11030467
