Τίτλος:
Pregnancy in Women With Preexisting Glomerular Diseases: A Single-Center
Experience
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
AimWomen with glomerular diseases are often of childbearing age. Besides
lupus nephritis, data regarding pregnancy in patients with glomerular
diseases are limited, posing a challenging task to attending
nephrologists. This study aimed to investigate the pregnancy outcomes
and the impact on the underlying glomerular disease among women followed
in our institution. MethodsA single-center retrospective cohort study of
women with biopsy-proven glomerular diseases who experienced pregnancy
between 2010 and 2020. We analyzed data before, during, and after
gestation. ResultsA total of 22 women, 13 women with primary and 9 women
with secondary glomerular diseases, were included in this study. Most
patients (82%) had received immunosuppressive treatment at various
times before pregnancy. All the women were in remission, either complete
(62%) or partial (38%), with well-preserved renal function (82%)
before conception. A total of 30 live births and 1 stillbirth were
recorded; the rate of preterm delivery was 23%. Renal function and
proteinuria remained stable during pregnancy. Preeclampsia was observed
in 6.7% of patients and disease relapse in 6.9% of the pregnancies.
ConclusionPregnancy was associated with a low frequency of adverse
events in women with underlying glomerular diseases, provided they have
quiescent disease and preserved renal function.
Συγγραφείς:
Marinaki, Smaragdi
Tsiakas, Stathis
Skalioti, Chrysanthi and
Kapsia, Eleni
Lionaki, Sophia
Vallianou, Kalliopi
Boletis,
John
Περιοδικό:
Frontiers in Cardiovascular Medicine
Εκδότης:
Frontiers Media SA
Λέξεις-κλειδιά:
pregnancy; glomerular diseases; lupus nephritis; outcomes; maternal;
fetal; relapse
DOI:
10.3389/fmed.2022.801144
