Τίτλος:
Novel prioritisation strategies for evaluation of temporal trends in
archived white-tailed sea eagle muscle tissue in non-target screening
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Environmental monitoring studies based on target analysis capture only a
small fraction of contaminants of emerging concern (CECs) and miss
pollutants potentially harmful to wildlife. Environmental specimen
banks, with their archived samples, provide opportunities to identify
new CECs by temporal trend analysis and nontarget screening. In this
study, archived white-tailed sea eagle (Haliaeetus albicilla) muscle
tissue was analysed by non-targeted high-resolution mass spectrometry.
Univariate statistical tests (Mann-Kendall and Spearman rank) for
temporal trend analysis were applied as prioritisation methods. A
workflow for non-target data was developed and validated using an
artificial time series spiked at five levels with gradient
concentrations of selected CECs (n = 243). Pooled eagle muscle tissues
collected 1965-2017 were then investigated with an eightpoint time
series using the validated screening workflow. Following peak detection,
peak alignment, and blank subtraction, 14 409 features were considered
for statistical analysis. Prioritisation by time-trend analysis detected
207 features with increasing trends. Following unequivocal molecular
formula assignment to prioritised features and further elucidation with
MetFrag and EU Massbank, 13 compounds were tentatively identified, of
which four were of anthropogenic origin. These results show that it is
possible to prioritise new CECs in archived biological samples using
univariate statistical approaches.
Συγγραφείς:
Durig, Wiebke
Alygizakis, Nikiforos A.
Menger, Frank and
Golovko, Oksana
Wiberg, Karin
Ahrens, Lutz
Περιοδικό:
Journal of Hazardous Materials
Λέξεις-κλειδιά:
Non-target analysis; Environmental specimen bank; White-tailed sea
eagle; LC-QToF-MS; Temporal trend analysis
DOI:
10.1016/j.jhazmat.2021.127331
