Τίτλος:
Quantifying the effect of in-hospital antimicrobial use on the
development of colistin-resistant Acinetobacter baumannii strains: a
time series analysis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objectives Colistin is currently considered an essential therapeutic
option for the treatment of hospital-acquired infections caused by
resistant isolates of Acinetobacter baumannii. In this study, conducted
in a tertiary care hospital, the effect of previous detection rates and
antimicrobial use on colistin-resistant A. baumannii strains was
investigated. Methods Susceptibility data for A. baumannii isolates and
colistin use information were collected for 48 consecutive months
(January 2014 to December 2017). ARIMA models were used to explore the
time series of colistin use and resistance to A. baumannii. In addition,
dynamic regression models were used to study the relationships between
the use of antimicrobials (colistin, imipenem, meropenem, cefepime,
ciprofloxacin) and colistin resistance. Results The results of the
univariate model showed a statistically significant positive association
between colistin use and the detection rate of colistin-resistant A.
baumannii (p=0.003). Moreover, a multivariate model confirmed the
positive association of colistin use with the detection rate of
colistin-resistant A. baumannii, also demonstrating statistically
significant negative associations with imipenem (p=0.004) and meropenem
use (p=0.005). Conclusions This study quantifies the effect of colistin
use on the development of resistant strains. These findings can assist
antimicrobial stewardship teams to elaborate their plans and predict the
effect of their interventions.
Συγγραφείς:
Kousovista, Rania
Athanasiou, Christos
Liaskonis, Konstantinos
and Ivopoulou, Olga
Karalis, Vangelis D.
Περιοδικό:
European Journal of Hospital Pharmacy : Science and Practice
Εκδότης:
BMJ Publishing Group
Λέξεις-κλειδιά:
pharmacy administration; health services administration; pharmacy
service; hospital; drug misuse; statistics
DOI:
10.1136/ejhpharm-2020-002606
