Τίτλος:
Social withdrawal as a trans-diagnostic predictor of short-term
remission: a meta-analysis of five clinical cohorts
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Social withdrawal is an early manifestation of several neuropsychiatric
disorders, and it is characterised by a gradual disengagement from
social interactions, potentially leading to complete isolation. This
study investigated the association between social withdrawal at baseline
and short-term symptom remission in five independent cohorts, including
patients with major depressive disorder (MDD), bipolar spectrum
disorders, and schizophrenia. Measures of social withdrawal were derived
in each study, and clinical remission was estimated based on the
psychopathological severity assessed after short-term
psychopharmacological treatment (12 weeks). Logistic regression was
performed in each sample, adjusting for age and baseline
psychopathological severity residualised for social withdrawal. Results
were then meta-analysed across samples within a random-effect framework.
A total of 4461 patients were included in the analyses (3195 patients
with MDD, 655 with bipolar spectrum disorders and 611 with
schizophrenia). The meta-analysis showed that higher baseline levels of
social withdrawal were associated with a decreased likelihood of
short-term remission (ORadj = 0.67, 95% CI, 0.58-0.79, P = 5.28 x
10(-7)), with the strongest effect in patients with schizophrenia.
Overall, our study highlighted the need to address social withdrawal in
the early phases of the disease to promote symptom remission in patients
with major psychiatric disorders. Understanding the neurobiology
underlying social withdrawal may aid the development of medications that
can specifically reverse social impairment, thereby fostering clinical
remission.
Συγγραφείς:
Oliva, Vincenzo
Fanelli, Giuseppe
Kasper, Siegfried
Zohar,
Joseph
Souery, Daniel
Montgomery, Stuart
Albani, Diego and
Forloni, Gianluigi
Ferentinos, Panagiotis
Rujescu, Dan and
Mendlewicz, Julien
Kas, Martien J.
De Ronchi, Diana
Fabbri,
Chiara
Serretti, Alessandro
Περιοδικό:
International Clinical Psychopharmacology
Εκδότης:
Lippincott, Williams & Wilkins
Λέξεις-κλειδιά:
bipolar disorder; major depressive disorder; psychopharmacology;
remission; social withdrawal; schizophrenia; transdiagnostic
DOI:
10.1097/YIC.0000000000000384
