Τίτλος:
Exercise as a mean to reverse the detrimental effect of high-fat diet on bone’s fracture characteristics
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The aim of this study is to investigate whether exercise can reverse some of the adverse effects of high-fat-diet-induced obesity on lipid metabolism and bone biomechanical properties. A total of 26 adult male C57bl/6J mice were randomly assigned into three groups: (A) Control group (n=6), (B) High-fat diet group (n=10), (C) High-fat diet and exercise group (n=10). Body mass and relevant biochemical parameters were measured for the duration of the experimental protocol (37 weeks). Mechanical strength of both femurs of each animal was assessed in-vitro based on three point bending tests. It was revealed that exposure to high-fat diet led to significant increase of body mass and cholesterol levels and also to substantial changes in bone morphology and strength. Ultimate stress for the animals exposed to high-fat diet and those exposed to high-fat-diet and exercise was 25% and 24% lower compared to control, respectively. Exercise increased bone thickness by 15% compared to animals that were not exposed to exercise. It was concluded that high-fat-diet appears to have a detrimental effect on bone biomechanics and strength. Exercise reversed the reduction in bone thickness that appears to be induced by high-fat diet. However no statistically significant increase in bone strength was observed. © 2017, Gruppo Italiano Frattura. All rights reserved.
Συγγραφείς:
Doulamis, I.
Perrea, D.N.
Chatzistergos, P.E.
Mitousoudis, A.S.
Kourkoulis, S.K.
Περιοδικό:
Frattura ed Integrita Strutturale
Εκδότης:
Gruppo Italiano Frattura
Λέξεις-κλειδιά:
Bending strength; Bending tests; Biomechanics; Mammals, Bone biomechanics; Femur; High-fat diet; Mice; Three point bending, Bone
DOI:
10.3221/IGF-ESIS.40.08
