Τίτλος:
Vibrational bone characteristics versus bone density for the assessment of osteoporosis in ovariectomized rats
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Our previous research findings suggested this integrated study in order to monitor changes of bone properties and assess bone integrity using vibrational characteristics in osteoporosis. The method is based on measurement of the bone dynamic characteristic modal damping factor (MDF). The experimental animal model is ovariectomized rat followed by alendronate treatment. According to the experimental design, adult female Wistar rats are ovariectomized and 60 days later, with confirmed osteoporosis, the population is divided into two groups. One is administered alendronate and the second is given no treatment. Furthermore, established techniques such as pQCT and histomorphometry are applied at all time points, in order to compare and correlate to MDF. The results indicate induction of osteoporosis due to ovariectomy and render MDF capable of monitoring changes in bone material properties and architecture, with high sensitivity and repeatability. © 2009 Informa UK Ltd.
Συγγραφείς:
Anastassopoulos, G.
Panteliou, S.
Christopoulou, G.
Stavropoulou, A.
Panagiotopoulos, E.
Lyritis, G.
Khaldi, L.
Varakis, J.
Karamanos, N.
Περιοδικό:
Journal of Medical Engineering and Technology
Λέξεις-κλειδιά:
Adult females; Alendronate; Bone density; Bone materials; Dynamic characteristics; Experimental animals; Experimental design; High sensitivity; Histomorphometry; Modal damping; Monitoring change; Time points, Damping; Fluorine containing polymers; Interconnection networks; Rats, Bone, alendronic acid, animal experiment; animal model; article; bone densitometry; bone density; bone mass; comparative study; controlled study; experimental model; female; modal damping factor; morphometrics; nonhuman; osteoporosis; ovariectomy; rat; sensitivity analysis; vibration, Alendronate; Animals; Bone Density; Disease Models, Animal; Female; Fourier Analysis; Linear Models; Osteoporosis; Ovariectomy; Ovary; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Statistics, Nonparametric; Tibia; Vibration
DOI:
10.3109/03091900903324056
