Τίτλος:
INCREASED MEAN SERUM THYROTROPIN IN APPARENTLY EUTHYROID
HYPERCHOLESTEROLEMIC PATIENTS - DOES IT MEAN OCCULT HYPOTHYROIDISM
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Serum thyroid hormones and antithyroid autoantibodies (AAB) were assayed
in 87 randomly selected hypercholesterolemic persons compared to 80
controls with normal serum total cholesterol (TC). Of the 87
hypercholesterolemic persons 22 (25%) had positive AAB compared to 5
(6%) controls. Furthermore, 8 of the hypercholesterolemic patients had
a serum TSH level above 5 mU/1, i.e. they had subclinical
hypothyroidism, not diagnosed before, whereas thyroid function was
normal in all normocholesterolemic persons. The new and unexpected
finding was that the hypercholesterolemic persons had on average a
significantly higher serum TSH than the controls, and this was true even
when persons with positive AAB were excluded. There was a significant
correlation between TC and serum TSH. It is concluded that
hypothyroidism may not be an all-or-none phenomenon, and that many
hypercholesterolemic persons with thyroid tests within the conventional
normal range may have a slight impairment of their thyroid function.
Συγγραφείς:
PALLAS, D
KOUTRAS, DA
ADAMOPOULOS, P
MARAFELIA, P and
SOUVATZOGLOU, A
PIPERINGOS, G
MOULOPOULOS, SD
Περιοδικό:
Journal of Endocrinological Investigation
Εκδότης:
EDITRICE KURTIS S R L
Λέξεις-κλειδιά:
ANTITHYROID AUTOANTIBODIES; CHOLESTEROL; HYPERCHOLESTEROLEMIA;
HYPOTHYROIDISM; SUBCLINICAL HYPOTHYROIDISM
