Τίτλος:
EFFECT OF ACUTE CHANGES IN AORTIC PRESSURE ON THE CORONARY RESERVE
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Study objective - The aim was to evaluate the effect of acute changes in
aortic pressure on the coronary reserve and hyperaemic response.
Design - Aortic pressure changes were induced either by intra-aortic
balloon pumping or by the production of acute aortic regurgitation. A
transient 20 s occlusion of the left anterior descending coronary artery
was used as the hyperaemic stimulus Experimental subjects - The
experiments were performed on 19 open chest anaesthetised dogs, weight
13-32 kg.
Measurements and main results - During intra-aortic balloon pumping the
mean diastolic aortic pressure increased by 24.7(SEM 2.9) mm Hg (p <
0.001), while in aortic regurgitation it decreased by 47.7(11.1) mm Hg
(p < 0.01). At the peak hyperaemic response the driving coronary
pressure was 121.4(2.8) mm Hg during intra-aortic balloon pumping and
59.8(11.5) mm Hg during aortic regurgitation. The peak hyperaemic flow
increased by 12.0(3.8) ml.min-1 (p < 0.01) during intra-aortic balloon
pumping, compared to the values before pumping and decreased by
14.9(4.2) ml.min-1 (p < 0.01) during aortic regurgitation, compared to
the values before aortic regurgitation. The coronary reserve, expressed
as the ratio of the hyperaemic to the resting flow, increased by
0.7(0.1) (p < 0.001) during intra-aortic balloon pumping and decreased
by 0.4(0.2) (p < 0.05) during aortic regurgitation. A positive
significant correlation coefficient was found at the peak hyperaemic
response between the mean aortic pressure and the total forward
effective coronary flow, and between the mean diastolic aortic pressure
and the diastolic component of the coronary flow, during both
intra-aortic balloon pumping and aortic regurgitation.
Conclusions - The results suggest that coronary reserve increases during
intra-aortic balloon pumping and decreases during aortic regurgitation;
these changes could be attributed to the effect of the pressure changes
on the hyperaemic flow.
Συγγραφείς:
ANTONATOS, PG
FOUSSAS, SG
NANAS, SN
KARAMOUSSALIS, DG and
THEOCHARIS, AG
ANTHOPOULOS, LP
MOULOPOULOS, SD
Περιοδικό:
Cardiovascular Research
Εκδότης:
ELSEVIER SCIENCE BV
Λέξεις-κλειδιά:
CORONARY RESERVE; AORTIC PRESSURE; INTRAAORTIC BALLOON PUMPING; AORTIC
REGURGITATION
DOI:
10.1093/cvr/25.12.995
