Τίτλος:
TUMOR-MARKERS IN PATIENTS UNDERGOING HEMODIALYSIS OR
KIDNEY-TRANSPLANTATION
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The following tumor markers, AFP, CEA, CA 19-9, CA-125 and CA 15-3 were
studied in 50 healthy volunteers (group A), in 23 patients on chronic
hemodialysis (group B) and in 30 successfully transplanted individuals
(group C) who did not present any clinical symptoms or signs of
neoplasia. The levels of AFP, CEA and CA 15-3 were significantly higher
in group B when compared to groups A and C. The levels of CA 19-9 and
CA-125 did not differ significantly among the three groups. Transplanted
individuals (group C) presented significantly lower levels of CEA and
AFP and higher levels of CA 15-3 when compared to group B patients. The
levels of all markers were not influenced by sex or time on dialysis. It
is concluded that: (1) CA 19-9 and CA-125 can be considered as reliable
tumor markers in patients undergoing hemodialysis or kidney
transplantation. (2) The elevation of CEA and AFP levels in hemodialysis
and their decline to normal levels found in the group of successfully
transplanted individuals, suggest a possible active role of functioning
renal tissue in their clearance. (3) The etiology of CA 15.3 elevation
following successful kidney transplantation remains obscure and requires
further evaluation.
Συγγραφείς:
ZEFEROS, N
DIGENIS, GE
CHRISTOPHORAKI, M
ALEXOPOULOS, I and
KOSTAKIS, A
GYFTAKI, H
MOULOPOULOS, S
Λέξεις-κλειδιά:
CANCER; ALPHA-FETOPROTEIN; CARCINOEMBRYONIC ANTIGEN; DIALYSIS; KIDNEY
GRAFT
