Τίτλος:
MEGALOMASTIA - HISTOLOGICAL, HISTOCHEMICAL AND IMMUNOHISTOCHEMICAL STUDY
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Megalomastia is a rare entity characterized by an uncommon enlargement
of both breasts. Unilateral megalomastia is extremely rare. The purpose
of this study was to collect information concerning the history of
patients with this condition and to investigate its histology in order
to outline the profile of this peculiar entity. Fifty cases of
megalomastia were studied. In 41 data concerning the history of the
patients was complete; there were 32 juvenile, 7 gravid and 2 adult type
cases. All three unilateral megalomastias were in the juvenile group. A
family history of megalomastia was frequently present: gravid
megalomastia was more closely connected with a maternal familial
history. A case of simultaneous megalomastia in monozygotic twins is
included. The final size achieved by the breasts was independent of the
type of megalomastia, the rapidity of breast development and the body
weight of the patients. It was greater in breasts containing abundant
adipose tissue and less in fibrous breasts. In all cases of megalomastia
associated with pregnancy the breasts had lost the ability to produce
milk. The main histological feature in all cases was severe damage and
destruction of the lobular units associated with extensive fibrosis. In
some breasts of all three types of megalomastia ramified new ducts named
“juvenile units” had developed and had proceeded to atrophy.
Immunohistochemistry revealed that the epithelium of these units was
negative for oestrogen and positive to progesterone receptors. A
biphasic pathological appearance, consisting of atrophic lobular units
and “juvenile units”, is diagnostic of megalomastia.
Συγγραφείς:
ANASTASSIADES, OT
CHOREFTAKI, T
IOANNOVICH, J
GOGAS, J and
PAPADIMITRIOU, CS
Περιοδικό:
VIRCHOWS ARCHIV A-PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY
Λέξεις-κλειδιά:
MEGALOMASTIA; LOBULAR DESTRUCTION; IMMUNOHISTOCHEMISTRY
