Τίτλος:
SOLID-PHASE SYNTHESIS OF A SOMATOSTATIN AMIDE ANALOG USING ACID LABILE
TERT-BUMEOC PROTECTION AND AN ACID LABILE ANCHOR GROUP
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The solid phase synthesis of an amidated somatostatin analogue based on
the principle of differentiated acidolysis is described. The acid labile
and smoothly cleavable t-Bumeoc moiety (1% TFA/DCM) is used for
temporary N(alpha)-protection of D- and L-amino acids and
[4-[[[9H-fluoren-9-yl-methoxycarbonyl]amino](4-methoxyphenyl)met
hyl]-2-methylphenoxy]acetic acid, attached to an aminomethylated
polystyrene resin is used as acid sensitive linker of the solid carrier
which releases the peptide in its amide form by treatment with TFA. Its
preparation is described in detail.
Συγγραφείς:
VOELTER, W
BREIPOHL, G
TZOUGRAKI, C
JUNGFLEISCHTURGUT, E
Περιοδικό:
Collection of Czechoslovak Chemical Communications
Εκδότης:
INST ORGANIC CHEM AND BIOCHEM
DOI:
10.1135/cccc19921707
