Τίτλος:
IN-VIVO POTENTIATION OF POLYMORPHONUCLEAR LEUKOCYTE CHEMOTAXIS BY
CLINDAMYCIN
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Polymorphonuclear leukocyte (PMNL) chemotaxis was evaluated in ten
healthy volunteers who had received 600 mg of clindamycin
intramuscularly. Serum obtained 3 hours after the administration of
clindamycin significantly increased PMNL chemotaxis. Serum obtained at
12 and 24 hours after the administration of the drug did not induce
significant increase in PMNL chemotaxis. The administration of
clindamycin had no direct effect on the PMNLs in terms of their
chemotactic activity. These results demonstrate serum-associated
augmentation of PMNL chemotaxis by clindamycin in vivo which may be of
potential clinical benefit in the outcome of infections.
Συγγραφείς:
SKOUTELIS, AT
LIANOU, PE
BASSARIS, HP
Περιοδικό:
INFECTIOUS DISEASES NOW
Εκδότης:
MMW MEDIZIN VERLAG GMBH
