Περίληψη:
The ability of high viscosity hydroxypropylmethylcellulose (HPMC) to
reduce postprandial glucose concentrations was assessed in patients with
non-insulin-dependent diabetes (NIDDM) and healthy volunteers. The study
design consisted of a two-way crossover, single-dose administration of
10 g prehydrated high viscosity HPMC, or placebo, with a standard
carbohydrate-rich meal. In patients with NIDDM, HPMC reduced blood
glucose concentrations at the 60-, 75-, 90-, 120- and 150-min sampling
intervals, with an average reduction in the maximum postprandial blood
glucose concentration, C(max) of 24% (P < 0.05). The time at which the
maximum concentration was reached, T(max), remained unchanged. The area
under the blood concentration versus time plot, AUC0-6h, was reduced by
an average of 15% (P < 0.05). The blood concentration profile of
insulin followed that of glucose. Concentrations were significantly
lower than in the placebo phase only at the 120-min sampling time, while
pharmacokinetic parameters (C(max), T(max) and AUC0-6h) were unchanged.
These results suggest that alterations in the blood glucose profile are
mediated by luminal events rather than by changes in hormonal response.
In contrast to the NIDDM patients, neither the pharmacokinetic
parameters nor the blood glucose concentrations at specific sampling
times were significantly affected by the co-administration of HPMC in
healthy volunteers. Overall, the results of this study suggest that HPMC
may be a useful adjunct in the management of NIDDM.
Συγγραφείς:
REPPAS, C
ADAIR, CH
BARNETT, JL
BERARDI, RR
DUROSS, D
and SWIDAN, SZ
THILL, PF
TOBEY, SW
DRESSMAN, JB
