Περίληψη:
HLA-A, -B and -DR antigen distribution was studied in 49 girls with
Turner Syndrome (TS), in 43 of their parents, as well as in 433
controls. No increased frequency of DR3, DR4 was found in our group.
However, an increased frequency of HLA B17 antigen was disclosed (18.3%
in TS versus 6.4% in the controls, p<0.001 and p(c<)0.01). Furthermore,
the HLA B17 antigen was of paternal origin in 77.7% of the cases. The
interpretation of the present findings is quite difficult. Most likely,
the findings are related to the chromosomal abnormality rather than to
autoimmunity. It is quite possible that genes within the region of class
I genes create unfavorable circumstances leading to the loss of the sex
chromosome or, alternatively, genes in this region confer protection and
prevent miscarriage of the affected fetus.
Συγγραφείς:
DACOUVOUTETAKIS, C
GEORGOPOULOS, N
PAPPA, H
VLACHOS, K and
TARASSI, K
CHRYSSOVERGI, D
PAPASTERIADES, C
