Τίτλος:
THYROID AUTOANTIBODIES AND THYROID-FUNCTION IN PATIENTS WITH
GASTRIC-CANCER
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Antibodies against thyroid antigens are commonly found in patients with
chronic gastritis type B (20-30%) and pernicious anaemia (50%), two
disorders that predispose to gastric cancer. In addition, thyroid
disease in increased incidence has been reported in breast and in colon
cancer. In order to determine a) the incidence of antithyroid antibodies
(ATA) in gastric cancer, b) the thyroid function in patients with ATA
and c) the correlation between ATA and the presence of chronic
gastritis, we examined the sera of 32 patients with gastric cancer (GC)
for the presence of antithyroglobulin and antimicrosomal antibodies,
T-3, T-4 and TSH values were also measured. The sera of 36 patients with
malignant tumours of the GI tract other than stomach (OMT) and of 40
healthy blood donors were used as controls. Three of the 32 GC patients
had antithyroglobulin antibodies, 4 had antimicrosomal and one had both
types. Of the eight patients with ATA (25%) only two had hypothyroidism
and another two histologically diagnosed chronic gastritis. Three sera
of the healthy controls and one of the OMT had also antithyroid
antibodies. To conclude, a significant number of patients with GC had
ATA as compared to controls (p < 0.01) but the presence of ATA did not
necessarily indicate an abnormality of thyroid function, The presence of
antibodies did not correlate with chronic gastritis type B.
Συγγραφείς:
SYRIGOS, KN
KONSTANTOULAKIS, MM
CONSTANTOULAKIS, M and
MARAFELIA, P
KOUTRAS, D
GOLEMATIS, BC
Περιοδικό:
Acta Oncologica
Εκδότης:
Universitetsforlaget (Scandinavian University Press)
DOI:
10.3109/02841869409098454
