Τίτλος:
FREE-RADICAL RELATED MYOCARDIAL MITOCHONDRIAL DAMAGE FOLLOWING LIMB
ISCHEMIA-REPERFUSION
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective: The aim was to define the following: (1) if reperfusion of
ischaemic limbs could cause myocardial damage; (2) if reactive oxygen
metabolites are involved in such possible damage. Methods: Ten rats
underwent ischaemia-reperfusion of the lower limbs (group A) and 10
underwent the same procedure following treatment with ascorbic acid
(group B). Ten rats were used as a control group (group C. Results: The
incidence of severe myocardial mitochondrial damage and serum
malondialdehyde concentrations 30 min after reperfusion were both higher
in group A than in groups B and C [8/10, 2/10, and 0/10, p < 0.05 and
7.25(SEM 0.33), 5.30(0.26), and 4.89(0.23) mu mol.litre(-1), p < 0.05,
respectively]. Conclusions: Ischaemia-reperfusion of the lower limbs may
cause mitochondrial damage in the myocardium and reactive oxygen
metabolites could mediate this damage.
Συγγραφείς:
BASTOUNIS, E
HADJINIKOLAOU, L
PIKOULIS, M
TSIGRIS, C and
MARINOS, E
TOUTOUZAS, P
Περιοδικό:
Cardiovascular Research
Εκδότης:
ELSEVIER SCIENCE BV
Λέξεις-κλειδιά:
FREE RADICALS; REPERFUSION INJURY; PERIPHERAL VASCULAR DISEASE;
MYOCARDIAL PATHOLOGY
DOI:
10.1093/cvr/28.12.1868
