Περίληψη:
A study has been carried out on the incidence of non-hemolytic
transfusion reaction on a group of patients suffering from thalassemia.
Of this group, the rate of reactions per patient, based on the
relationship between the number of patients with nonhemolytic
transfusion reactions and the total number had risen to 31.8 %.
83.7 % of the patients with non-hemolytic transfusion reactions did not
give a positive reaction to lymphocytotixicity.
654 patients having, or not having shown a non-hemolytic transfusion
reaction received washed red cell concentrates prepared
extemporaneously. This process allowed the rate of reaction per patient
to drop to 3.9 %.
The transfusion of deleucocytated red cell concentrates by filtration,
carried out on a group of 188 patients, made the rate of reaction per
patient drop to 2.8 %.
As regards to rate reaction per patient; there is no significant
difference statistically between these two groups, however, it must be
pointed out that the administration of filtered red cell concentrates,
by deleucocytation, notably improves the incidence of a feverish
reaction, while the administration of washed red cell concentrates has
an important impact on allergic reactions. interestingly, in solution,
the washed red cell concentrates have the added advantage of having only
very small quantities of free iron or vascoactive proteic derivatives.
The new four bag system, now allows us to collect, separate and wash in
a closed circuit. Compared to the traditional method this system has the
advantage of assuring greater efficiency and security.
In conclusion, for the first time, the administration of washed red cell
concentrates on patients who receive regular transfusions, may represent
a good procedure, combined or not with deleucocytation by filtration, as
to prevent the occurrence of nonhemolytic reactions.
Συγγραφείς:
Spanos, T
Ladis, V
Karageorga, M
Theodori, H
Tzivaras, A
and Peristeri, J
Kattamis, C
