Τίτλος:
CARDIAC INVOLVEMENT IN COLLAGEN DISEASES
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The purpose of this study is to evaluate the early morphological and
functional abnormalities of the heart in patients with collagen disease.
The study population was free of risk factors for coronary artery
disease and without any clinically evident cardiac manifestations. In
62 patients with collagen disease (25 with progressive systemic
sclerosis, 19 with systemic lupus erythematosus, 15 with rheumatoid
arthritis, three with dermatomyositis) and in 40 healthy subjects an
echocardiographic study was performed. Echocardiographic examination
from the apical four-chamber view was performed at rest and during the
end of a 3 min isometric exercise with handgrip. Global and regional
ejection fraction of the left ventricle were calculated. In the group
with progressive systemic sclerosis the left ventricular mass index was
significantly higher than in the control group (110.78 +/- 48.61 vs
82.18 +/- 28.46 g . m-2) and the ejection fraction (53.61 +/- 7.95%)
was the lowest of all groups (control: 61.47 +/- 8.52%, systemic lupus
erythematosus: 59.04 +/- 8.58%, rheumatoid arthritis: 62.38 +/-
6.88%). Regional ejection fraction analysis revealed a major
dysfunction of the proximal segment of the interventricular septum, in
all groups. During isometric exercise, the global and regional ejection
fraction did not change significantly, although differences between
groups disappeared. In rheumatoid arthritis, mitral and aortic valve
leaflet separation appeared to be reduced. In the group with systemic
lupus erythematosus, mild abnormalities were noticed, although the mean
age and duration of the disease were the smallest compared with the
other groups. In conclusion, patients with progressive systemic
sclerosis mainly present left ventricular hypertrophy with a reduced
ejection fraction while rheumatoid arthritis patients show a predominant
value dysfunction. In patients with collagen disease, without clinical
signs of heart disease or risk factors for coronary artery disease,
there are early morphological and functional abnormalities probably due
to the primary disease.
Συγγραφείς:
TOUMANIDIS, ST
PAPAMICHAEL, CM
ANTONIADES, LG
PANTELIA, MI
and SARIDAKIS, NS
MAVRIKAKIS, ME
SIDERIS, DA
MOULOPOULOS, SD
Περιοδικό:
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
Εκδότης:
W B SAUNDERS CO LTD
Λέξεις-κλειδιά:
COLLAGEN DISEASE; PROGRESSIVE SYSTEMIC SCLEROSIS; RHEUMATOID ARTHRITIS;
SYSTEMIC LUPUS ERYTHEMATOSUS; ECHOCARDIOGRAPHY; EJECTION FRACTION
DOI:
10.1093/oxfordjournals.eurheartj.a060893
