Τίτλος:
HEAT-SHOCK PROTEIN-70 AND HLA-DR MOLECULES TISSUE EXPRESSION -
PROGNOSTIC IMPLICATIONS IN COLORECTAL-CANCER
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
PURPOSE: The expression of 70,000-Da heat shock protein (HSP 70) and
HLA-DR molecules on cancer cells influences immunologic mechanisms that
may be of some prognostic significance. The purpose of this study was to
examine the relationship among immunohistochemical HSP 70, HLA-DR
expression, and clinicopathologic tumor variables, as well as patient
survival in a series of 128 colorectal carcinomas. METHOD: A three-step
immunoperoxidase staining technique was undertaken for detection of both
markers. RESULTS: Of the examined carcinomas 77.3 percent were HSP
70-positive and 74.2 percent were HLA-DR-positive. Increased HSP
70-positive expression correlated significantly with low differentiation
(P < 0.05), showed a tendency to characterize advanced stages of
disease, and was clearly associated with worse overall survival (P <
0.05). The highest rate of HLA-DR positivity was demonstrated in early
stages and was significantly associated with more favorable prognosis (P
< 0.001). HSP 70-positive/HLA-DR-negative patients had worse overall
survival compared with the rest (P < 0.001). CONCLUSIONS: The resulting
opposite effects on prognosis of examined markers seem to be related to
different pathophysiologic functional roles on tumor immunology.
Συγγραφείς:
LAZARIS, AC
THEODOROPOULOS, GE
DAVARIS, PS
PANOUSSOPOULOS, D
and NAKOPOULOS, L
KITTAS, C
GOLEMATIS, BC
Περιοδικό:
Diseases of the Colon & Rectum
Εκδότης:
Lippincott, Williams & Wilkins
