Τίτλος:
ORAL-CONTRACEPTIVES, MENOPAUSAL ESTROGENS, AND THE RISK OF BREAST-CANCER
- A CASE-CONTROL STUDY IN GREECE
Περίληψη:
In a hospital-based case-control study in Athens, we examined the
association between the use of oral contraceptives and menopausal
estrogens and the risk of breast cancer. Eight hundred and twenty
patients with confirmed breast cancer were compared with 795 orthopedic
patient controls and 753 healthy visitor controls, matched to the cases
by age and interviewer. The data were modeled through logistic
regression, controlling for demographic and reproductive variables. Odds
ratio patterns were similar for the 2 control series, which were
therefore combined to increase precision of the estimates. The risk for
breast cancer was not elevated among ever-users of oral contraceptives,
regardless of age at diagnosis of breast cancer, duration of oral
contraceptive use or timing of use in relation to first full-term
pregnancy. Among peri- and post-menopausal women who ever used
menopausal estrogens, with never-users as the baseline, a statistically
significant elevated odds ratio was found after adjusting for age at
menopause. (C) 1995 Wiley-Liss, Inc.
Συγγραφείς:
LIPWORTH, L
KATSOUYANNI, K
STUVER, S
SAMOLI, E and
HANKINSON, SE
TRICHOPOULOS, D
