Περίληψη:
We have examined the relation of lactation, by total duration, with
breast cancer risk among pre- and post-menopausal women. In a
hospital-based case-control study conducted in Athens (1989-91),
involving 820 patients with confirmed breast cancer and 795 orthopaedic
patient controls and 753 hospital visitor controls, logistic regression
was used to analyse the data controlling for demographic, nutritional
and reproductive factors, including parity and age at any birth. Among
post-menopausal women, there was no association between breastfeeding
and breast cancer risk, but among premenopausal women those who had
breastfed for greater than or equal to 24 months had an odds ratio of
0.50 (95% confidence interval 0.23 - 1.41). A reduction of the odds
ratio was also evident among premenopausal women who had breastfed
between 12 and 23 months (odds ratio 0.70; 95% confidence interval
0.34-1.60). In conjunction with several other recent reports these
results support the hypothesis that breastfeeding of prolonged duration
may reduce the risk of breast cancer among premenopausal women but not
among post-menopausal women. The biology underlying this different
effect remains unknown, and the practical implication of the finding is
of marginal importance.
Συγγραφείς:
Katsouyanni, K
Lipworth, L
Trichopoulou, A
Samoli, E and
Stuver, S
Trichopoulos, D
