Τίτλος:
Intracoronary cyclic-GMP and cyclic-AMP during percutaneous transluminal
coronary angioplasty
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
We investigated intracoronary cyclic-guanosine monophosphate (c-GMP)
levels during percutaneous transluminal coronary angioplasty (PTCA)
since experimental studies have shown the endothelial origin of c-GMP
production. Intracoronary c-GMP and cyclic adenosine monophosphate
(c-AMP) were measured during coronary angioplasty in 24 patients with
chronic coronary artery disease. Four coronary blood samples were taken
through a catheter from the coronary artery the first sample before
coronary angiography and the other three from distal to coronary
obstruction, as follows: before the balloon inflation, at the maximum
inflation and 5 min after restoration of coronary flow. c-GMP increased
from 7.9 +/- 1.0 pmol/ml and 7.5 +/- 0.9 pmol/ml before angiography and
balloon inflation to 11.1 +/- 1.3 pmol/ml at the maximum inflation (P <
0.01), with a trend to decrease 5 min after the end of the intervention
(9.5 +/- 1.3 pmol/ml, P: NS). Intracoronary c-AMP levels remained almost
unchanged. Five venous samples were taken to measure c-AMP before
coronary angiography, before PTCA, and 5 min, 2 h and 24 h after PTCA.
c-AMP values 2 and 24 h after PTCA (17.8 +/- 1.7 pmol/ml and 17.5 +/-
1.7 pmol/ml, respectively) were lower than the highest value (22.1 +/-
2.1 pmol/ml) found 5 min after PTCA, (P < 0.001). c-GMP increases distal
to coronary obstructive lesion during PTCA at the time of balloon
inflation, while c-AMP remains unchanged. c-AMP rises in venous
circulation only. PTCA stimulates the mechanism of c-GMP release, while
systemic c-AMP increase seems to be related to the stress occurring
during catheterisation and PTCA.
Συγγραφείς:
Kremastinos, DT
Iliodromitis, EK
Markianos, M
Apostolou, TS
and Kyriakides, ZS
Karavolias, GK
Περιοδικό:
International Journal of Cardiology
Εκδότης:
ELSEVIER SCI IRELAND LTD
Λέξεις-κλειδιά:
cyclic-guanosine monophosphate (c-GMP); percutaneous transluminal
coronary angioplasty
DOI:
10.1016/0167-5273(95)02539-1
