Τίτλος:
Hepatic stimulator substance administration affects cadmium-induced
hepatotoxicity in the rat
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The effect of hepatic stimulator substance (HSS) administration on
cadmium (Cd) induced hepatotoxicity was studied in the rat. HSS was
extracted from the liver of weanling rats (Hepatology 1985; 7: 100-106).
Rats were injected with 2.5 mg CdCl2/kg body weight to induce acute
liver injury, evaluated 24 h later. Serum enzyme activities of alanine
aminotransferase (ALT), aspartate aminotransferase (AST) and
histological parameters were used for the estimation of Cd-induced
hepatotoxicity. HSS, at doses of 10, 20 and 30 mg protein/kg body
weight, injected 10 h after Cd administration, caused dose-dependent
decrease of hepatic injury. HSS suppressed the elevation of AST and ALT
induced by Cat in a dose-dependent manner. Liver histological changes
indicated that HSS reduced the severity of hepatic lesion induced by Cd
administration and reversed Cd-induced hepatotoxicity. In conclusion,
our results suggest that HSS administration protects the liver against
Cd-induced injury.
Συγγραφείς:
Margeli, AP
Theocharis, SE
Spiliopoulou, C
Horti, M and
Koutselinis, A
Περιοδικό:
International Hepatology Communications
Εκδότης:
ELSEVIER SCI IRELAND LTD
Λέξεις-κλειδιά:
hepatic stimulator substance; cadmium; liver; toxicity
DOI:
10.1016/0928-4346(96)00290-3
