Τίτλος:
A triclinic crystal form of the lectin concanavalin A
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The molecular structure of a triclinic crystal form of concanavalin A
has been refined at 2.4 Angstrom resolution. The crystals have unit cell
dimensions a 78.8 Angstrom, b = 79.3 Angstrom, c = 133.3 Angstrom, alpha
= 97.1 degrees, beta = 90.2 degrees, and gamma = 97.5 degrees and
contain two tetramers per asymmetric unit each with approximate 222
symmetry. The final crystallographic R-factor is 0.205 and the
free-R-factor is 0.265 in the resolution range 6.0 to 2.4 Angstrom The
conformation of the tetramer is more similar to that found in
concanavalin A saccharide complexes than in the previously reported I222
crystal form of uncomplexed concanavalin A. A comparison of the
molecular packing between the two crystal forms shows a more open
arrangement with large solvent channels through the crystal. (C) 1996
Academic Press, Inc.
Συγγραφείς:
Kanellopoulos, PN
Tucker, PA
Pavlou, K
Agianian, B and
Hamodrakas, SJ
Περιοδικό:
Journal of Structural Biology
Εκδότης:
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI:
10.1006/jsbi.1996.0065
