Τίτλος:
Evidence that adult life risk factors influence the expression of
familial propensity to breast cancer
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
In the context of a study in Athens comprising 692 cases and 1,261
controls, we have evaluated the effect on breast cancer risk of the
joint action of first-degree relative family history and established
adult life risk factors. We created a risk score by assigning the value
of 1 to women at high risk with respect to any of these risk factors and
0 otherwise, and summing these values, using weights equal to the excess
odds ratio. The odds ratio for a tertile increment in the risk score was
1.5 [95% confidence interval (CI) = 1.3-1.8] among women without
family history, and 2.3 (95% CI = 1.1-5.1) for women with family
history. Our findings imply that women with a family history of breast
cancer may benefit disproportionately by reduced exposure to adult life
risk factors.
Συγγραφείς:
Katsouyanni, K
Signorello, LB
Lagiou, P
Egan, K and
Trichopoulos, D
Περιοδικό:
Epidemiology Monitor
Εκδότης:
Lippincott, Williams & Wilkins
Λέξεις-κλειδιά:
familial breast cancer; risk factors; interaction; case control study
DOI:
10.1097/00001648-199709000-00019
