Τίτλος:
The risk profile of childhood leukaemia in Greece: a nationwide
case-control study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The risk profile of childhood leukaemia in Greece was studied through a
case-control investigation that included all 153 incident cases of the
disease, ascertained throughout the country during 1993 and 1994, and
two hospital controls for every case matched for gender, age and place
of residence. The data were analysed using conditional logistic
regression and the associations are expressed in terms of adjusted odds
ratios (OR) and their 95% confidence intervals. Cases were born to
mothers of a higher standard education, the OR for an increment of four
schooling years being 1.48 (1.17-1.87) and had higher birth weight, the
OR for an increment of 500 g being 1.36 (1.04-1.77). Pet ownership and
birth after a pregnancy with anaemia were associated with increased
risk, the ORs being 2.18 (1.14-4.16) and 2.60 (1.39-4.86) respectively.
From the frequency analyses, indicative inverse associations were found
with birth order, household crowding and previous hospitalization with
allergic diseases, whereas indicative positive associations were found
with diabetes mellitus during pregnancy and with neonatal jaundice.
Substantial or significant elevations were not found with respect to
maternal smoking and coffee drinking during pregnancy, diagnostic
radiography and ultrasonographic examinations or blood transfusions. A
significant inverse association with maternal consumption of alcohol
could be due to multiple comparisons, but a detrimental effect can
probably be excluded. A non-significant positive association with total
shots of viral vaccinations and a weak non-significant inverse
association with breast feeding were also found. We interpret the
findings of this study as being compatible with acute childhood
leukaemia being linked with delayed development of herd immunity to
fairly common infectious agents, in conjunction with accelerated
perinatal and early post-natal growth.
Συγγραφείς:
Petridou, E
Trichopoulos, D
Kalapothaki, V
Pourtsidis, A and
Kogevinas, M
Kalmanti, M
Koliouskas, D
Kosmidis, H and
Panagiotou, JP
Piperopoulou, F
Tzortzatou, F
Περιοδικό:
British Journal of Cancer
Εκδότης:
Churchill Livingstone
Λέξεις-κλειδιά:
childhood leukaemia; birthweight; herd immunity; pet ownership
DOI:
10.1038/bjc.1997.541
