Τίτλος:
Spatial temporal patterns in childhood leukaemia: further evidence for
an infectious origin
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The EUROCLUS project included information on residence at diagnosis for
13351 cases of childhood leukaemia diagnosed in the period 1980-89 in
defined geographical regions in 17 countries. A formal algorithm permits
identification of small census areas as containing case excesses. The
present analysis examines spatial-temporal patterns of the cases (n =
970) within these clustered areas. The objectives were, first, to
compare these results with those from an analysis conducted for UK data
for the period 1966-83, and, second, to extend them to consider infant
leukaemias. A modification of the Knox test investigates, within the
small areas, temporal overlap between cases in a subgroup of interest at
a putative critical time and all other cases at any time between birth
and diagnosis. Critical times were specified in advance as follows. for
cases of acute lymphoblastic leukaemia aged 2-4 years, the 18-month
period preceding diagnosis; for cases of total leukaemia aged 5-14
years, 1 year before to 1 year after birth; and for infant cases
(diagnosed < 1 year), 1 year before to 6 months after birth. Each of the
analyses found evidence of excess space-time overlap compared with that
expected; these were 10% (P = 0.005), 15% (P = 0.0002) and 26% (P=
0.03) respectively. The results are interpreted in terms of an
infectious origin of childhood leukaemia.
Συγγραφείς:
Alexander, FE
Boyle, P
Carli, PM
Coebergh, JW
Draper, GJ
and Ekbom, A
Levi, F
McKinney, PA
McWhirter, W
Magnani,
C
Michaelis, J
Olsen, JH
Peris-Bonet, R
Petridou, E and
Pukkala, E
Vatten, L
Περιοδικό:
British Journal of Cancer
Εκδότης:
Churchill Livingstone
Λέξεις-κλειδιά:
infection; childhood leukaemia; acute lymphoblastic leukaemia; delayed
exposure; infant leukaemia; in utero exposure; cluster
DOI:
10.1038/bjc.1998.132
