Περίληψη:
We performed a meta-analysis of over 30 case-control studies of
association between schizophrenia and a bi-allelic, BalI polymorphism in
exon 1 of the dopamine D3 receptor gene. We observed a significant
excess of both forms of homozygote in patients (P = 0.0009, odds ratio
(OR) = 1.21, 95% Confidence Interval (CI) = 1.07-1.35) in the combined
sample of 5351 individuals. No significant heterogeneity was detected
between samples and the effects did not appear to be the product of
publishing bias. In addition we undertook an independent, family-based
association study of this polymorphism in 57 parent/proband trios, taken
from unrelated European multiplex families segregating schizophrenia. A
transmission disequilibrium test (TDT) showed a significant excess of
homozygotes in schizophrenic patients (P = 0.004, odds ratio (OR)= 2.7,
95% CI = 1.35-5.86). Although no significant allelic association was
observed, a significant association was detected with the 1-1 genotype
alone (P = 0.02, OR = 2.32, 95% CI = 1.13-4.99). In addition when the
results of the family-based association study were included in the
meta-analysis, the homozygosity effect increased in significance (P =
0.0002, OR = 1.23, 95% CI = 1.09-1.38). The results of the
meta-analysis and family-based association study provide independent
support for a relationship between schizophrenia and homozygosity at the
BalI polymorphism of the D3 receptor gene, or between a locus in linkage
disequilibrium with it.
Συγγραφείς:
Williams, J
Spurlock, G
Holmans, P
Mant, R
Murphy, K and
Jones, L
Cardno, A
Asherson, P
Blackwood, D
Muir, W and
Meszaros, K
Aschauer, H
Mallet, J
Laurent, C
Pekkarinen,
P
Seppala, J
Stefanis, CN
Papadimitriou, GN
Macciardi, F
and Verga, M
Pato, C
Azevedo, H
Crocq, MA
Gurling, H and
Kalsi, G
Curtis, D
McGuffin, P
Owen, MJ
