Τίτλος:
Platelet MAO activity in patients with dysthymic disorder
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The aim of the present study was to examine possible associations
between platelet monoamine oxidase (MAO) activity and primary dysthymic
disorder. For that purpose we estimated the enzyme activity in 58
patients (15 males and 43 females) selected according to DSM-III-R
criteria and in 61 healthy controls (30 males and 31 females). Platelet
MAO activities were found significantly lower in the female patients
compared to female controls. Moreover, the enzyme activities were found
to be even lower in the female patients who had attempted suicide. These
differences did not exist in the male population. We could not find any
associations of MAO activity to the age of the patients, the age of
onset, the duration of dysthymia, or HAM-D and SCL-90R scores. Our
findings are consistent with the hypothesis that platelet MAO activity
is a trait-dependent indicator of vulnerability to dysthymic disorder
and suicidality in our female population. (C) 1998 Elsevier Science
Ireland Ltd.
Συγγραφείς:
Tripodianakis, J
Markianos, M
Sarantidis, D
Spyropoulou, G
and Taktikou, V
Bistolaki, E
Περιοδικό:
Psychiatry Research
Εκδότης:
Elsevier Ireland Ltd
Λέξεις-κλειδιά:
males/females; suicide attempt; depressive symptomatology
DOI:
10.1016/S0165-1781(98)00011-0
