Περίληψη:
The occurrence of p53, bcl-2 and heat shock protein (HSP) expression in
ovarian tumours was examined and the correlation was investigated
between the expression of these proteins and other disease parameters,
including FIGO stage, histological subtype, tumour differentiation and
steroid hormone receptor status. We analysed p53, bcl-2 and HSP
expression in 100 smears of patients with epithelial ovarian carcinomas,
16 smears of patients,vith borderline malignancy and 20 smears of
patients with benign ovarian neoplasms by using immunocytochemical
techniques. There were 29 patients,vith stage I disease, 24 with stage
II disease, 40 with stage III disease and seven with stage IV disease
according to the FIGO classification. The sensitivities and
specificities of bcl-2, p53 and HSP for malignancy were 53% and 40%,
43% and 80%, and 37% and 90%, respectively. HSP was statistically
significantly associated with malignant rather than benign tumours.
Significant association was also observed between bcl-2 and p53, and p53
and HSP. The association of HSP with malignant tumours is confined to
the premenopausal group of patients and in this group by itself there is
also a significant association between p53 and malignancy. HSP and p53
were associated with undifferentiated carcinomas, bcl-2 and p53
expression is reduced as disease stage progresses in serous carcinomas
and bcl-2 expression is increased as disease progresses in endometrioid
carcinomas. There was no significant association between bcl-2 and ER/PR
status. In conclusion, HSP has a high specificity for malignant ovarian
tumours, bcl-2 and p53 have only moderate to low sensitivity and
specificity. Changes in the frequency of bcl-2 and p53 overexpression
between FIGO I and FIGO III stage disease of different ovarian
carcinomas indicate a different role of these substances in cellular
survival mechanisms in different carcinomas. bcl-2 probably is
associated,vith cell proliferation but not with differentiation. (C)
1998 Lippincott-Raven Publishers.
Συγγραφείς:
Athanassiadou, P
Petrakakou, E
Sakelariou, V
Zerva, C and
Liossi, A
Michalas, S
Athanassiades, P
