Περίληψη:
The Pollution Effects on Asthmatic Children in Europe (PEACE) study is a
multicentre studs of the acute effects of particles with a 50% rut-off
aerodynamic diameter of 10 mu m (PM10), black smoke (BS), sulphur
dioxide (SOL) and nitrogen dioxide (NO2) on the respiratory health of
children with chronic respiratory symptoms,
The study was conducted in the winter of 1993/1994 by 14 research
centres in Europe. A total of 2,010 children, divided over 28 panels in
urban and suburban locations, was followed For at least 2 months.
Exposure to air pollution was monitored on a daily basis, Health status
was monitored hy daily peak expiratory how (PEF) measurements and a
symptom diary. The association between respiratory health and air
pollution levels was calculated with time series analysis. Combined
effect estimates of air pollution on PEI: or the daily prevalence of
respiratory symptoms and bronchodilator use were calculated from the
panel-specific effect estimates, Fixed effect models were used and, in
cases of heterogeneity, random effect models.
No clear associations between PM10, BS, SO2 or NO2 and morning PEF,
evening PEI, prevalence of respiratory symptoms or bronchodilator use
could be detected. Only previous day PM10 was negatively associated with
evening PEF, but only in locations where BS was high compared to PM10
concentrations. There were no consistent differences in effect estimates
between subgroups based on urban versus suburban, geographical location
or mean levels of PM10, BS, SO2 and NO2. The lack of association could
not be attributed to a lack of statistical power, low levels of exposure
or incorrect trend specifications,
In conclusion, the PEACE project did not show effects of particles with
a 50% cutoff aerodynamic diameter of IO pm, black smoke, sulphur
dioxide or nitrogen dioxide on morning or evening peak expiratory how or
the daily prevalence of respiratory symptoms and bronchodilator use.
Συγγραφείς:
Roemer, W
Hoek, G
Brunekreef, B
Haluszka, J
Kalandidi, A
and Pekkanen, J
PEACE Project
