Περίληψη:
Despite strong evidence provided by genetic epidemiology of genetic
involvement in the aetiology of bipolar and unipolar affective
disorders, the exact nature of the predisposing gene(s) is still being
investigated through linkage and association studies. The interaction of
susceptibility genes and environmental factors in these diseases is also
of fundamental importance and requires proper investigation. Interesting
theories have recently been proposed examining the possible role of
various chromosomal regions, candidate genes and mutations in affective
disorders. Reliable multicentre-based methodology is currently being
employed to examine these theories, with attention given to statistical
analysis and the statistical power of the sample. The present article
describes the European Collaborative Project on Affective Disorders
(ECPAD) ‘Interactions between genetic and psychosocial vulnerability
factors’, involving 15 European centres. A description is given of the
association and family samples collected for the project and also the
methodology used to analyse interactions in the gene-psychosocial
environment. This material provides a powerful tool in the search for
susceptibility genes in affective disorders and takes into account
non-genetic aetiological factors. Psychiatr Genet 8:197-205 (C) 1998
Lippincott Williams & Wilkins.
Συγγραφείς:
Souery, D
Lipp, O
Serretti, A
Mahieu, B
Rivelli, SK and
Cavallini, C
Ackenheil, M
Adolfsson, R
Aschauer, H and
Blackwood, D
Dam, H
Delcoigne, B
Demartelaer, V
Dikeos,
D
Fuchshuber, S
Heiden, M
Jablensky, A
Jakovljevic, M
and Kessing, L
Lerer, B
Macedo, A
Mellerup, T
Milanova,
V
Muir, W
Nylander, PO
Oruc, L
Papadimitriou, GN and
Pekkarinen, P
Peltonen, L
de Azevedo, MHP
Pull, C and
Shapira, B
Smeraldi, E
Staner, L
Stefanis, C
Verga, M
and Verheyen, G
Macciardi, F
Van Broeckhoven, C
Mendlewicz,
J
