Περίληψη:
Background: Leptin, the adipocyte-secreted protein product of the ob
gene, has been strongly linked to obesity and is believed to play a role
in the regulation of the reproductive system. This study examines the
potential influence of lifestyle and dietary factors, as well as of
other hormones, on serum levels of leptin. Methods: The authors studied
a population of 48 healthy elderly Greek men. Sera from these men were
analyzed for leptin, several steroid hormones, sex hormone-binding
globulin, and insulin-like growth factor 1. The authors also utilized
data from food frequency questionnaires and information on demographic,
anthropometric, and lifestyle (cigarette smoking, alcohol and coffee
drinking) factors. Results: Using linear regression modeling, serum
leptin levels were inversely associated with testosterone and positively
associated with estradiol and dehydroepiandrosterone sulfate, after
adjustment for the other hormones and body mass index (BMI). Leptin
levels in men with a BMI >30 kg/m(2) were 170% higher than in men with
a BMI <27 kg/m(2) (95% CI 63-346%). Height was also positively
associated with leptin, independent of BMI. No notable relationships
were observed between leptin, on the one hand, and smoking, alcohol
drinking, coffee drinking, or total energy intake, on the other. When
total energy intake was separated into its three major components
(carbohydrate, fat, and protein), it appeared that fat intake may have
an isocalorically differential effect on serum leptin levels; one
marginal quintile increase in fat intake corresponded to an 11%
increase in leptin (95% CI 0-24%). Conclusion: Serum levels of leptin
may be influenced by other endocrine factors, especially testosterone
and estradiol, and may be positively associated with excess fat intake
independently of obesity.
Συγγραφείς:
Lagiou, P
Signorello, LB
Mantzoros, CS
Trichopoulos, D and
Hsieh, CC
Trichopoulou, A
