Περίληψη:
The aim of this study was to clarify the significance of serum prolactin
concentrations in patients with infertility and endometriosis. Forty
patients with infertility and laparoscopically proven endometriosis were
recruited into the study. Basal serum prolactin levels and prolactin
levels after TRH administration were measured. The mean basal serum
prolactin concentrations were 12.5, 16.5, 19.5, and 26.5 ng/ml and those
after thyrotropin-releasing hormone (TRH) administration were 88.3,
114.2, 125.3 and 138.8 ng/ml in patients with stages I, II, III and IV
endometriosis, respectively. A statistically significant relationship
was found between the basal serum prolactin levels as well as those
after TRH injection and the stage of the endometriosis. The patients
were divided in two groups. Group I consisted of 20 patients who did not
receive any treatment, while group II consisted of 20 patients who were
initially treated with GnRH analogues for 24 week and subsequently with
several therapeutic schemes in order to improve their fecundity. The
pregnancy rate was not different between the two groups. The patients,
however, who did not become pregnant had higher serum prolactin
concentrations after TRH administration as compared to those who
conceived. We conclude that occult hyperprolactinemia may be a cause of
infertility in patients with endometriosis.
Συγγραφείς:
Gregoriou, G
Bakas, P
Vitoratos, N
Papadias, K
Goumas, K
and Chryssicopoulos, A
Creatsas, G
