Περίληψη:
Liver regeneration after injury with carbon tetrachloride (CCl4)
followed by partial hepatectomy is a complex model involving
toxicological, inflammatory, and necrotic processes. In the present
study, the time-course of hepatic regenerative process was investigated
in relation to hepatic stimulator substance (HSS) activity,
administration of a single dose of CCl4 and partial (70%) hepatectomy
in male rats. To evaluate liver injury events, the levels of serum
aspartic aminotransferase (AST), alanine aminotransferase (ALT), and
alkaline phosphatase (ALP) were measured. Hepatic DNA synthesis reached
a maximum at 36 hr after hepatectomy in contrast to the reported 24-hr
and 32-hr peaks observed in nontreated hepatectomized rats. On the other
hand, HSS activity appeared to peak at 28, 40, and 44 hr after
hepatectomy in CCl4-treated rats, and it was quite a lot lower at 24,
32, 36, 48, and 60 hr. The hypothesis that HSS promotes liver
regeneration but it does not initiate it, as other factors have been
found to do, is discussed.
Συγγραφείς:
Liakos, AA
Mykoniatis, MG
Kokala, ME
Papadimitriou, DG and
Liatsos, GD
