Τίτλος:
Cytogenetic analysis and RAS mutations in primary myelodysplastic
syndromes
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Cytogenetic analysis was performed in 60 patients with primary
myelodysplastic syndromes-diagnosed, treated, and followed in our
department. In 41 cases, the presence of the NRAS mutation was also
evaluated. The aim of this study was to evaluate the prognostic value of
chromosomal abnormalities and NRAS mutation. The median age of the
patients was 67 years (18-88 years), and the French-American-British
classification was as follows: refractory anemia 26, refractory anemia
with ring sideroblasts 4, refractory anemia with excess of blast cells
15, refractory anemia with ex-cess of blast cells in transformation 3,
and chronic myelomonocytic leukemia 12. Survival analysis was performed
for the patients with a normal (n = 35), an abnormal (n = 25) karyotype
and with a single (n = 25) or multiple (n = 10) cytogenetic
abnormalities. Abnormal karyotypes were detected in 25 of the 60
patients (41.6%). Fifteen of these patients had a single and 10 had two
or more lesions. The median survival of the patients with a normal (33.1
months) and with an abnormal (36.5 months) karyotype was not
significantly different. Patients with multiple lesions had a reduced
median survival compared with patients with single anomalies (19.2
versus 39.7 months, p = 0.5). Patients with an abnormal karyotype
progressed to acute leukemia more frequently compared with patients
without lesions (36 versus 28.6%, p = 0.5). NRAS mutation rr as
detected in 2 of 10 CMMoL patients studied and in none of the 31
patients with other types of myelodysplastic syndrome. Marrow blasts
more than 10% significantly affected survival. (C) Elsevier Science
Inc., 1999. All rights reserved.
Συγγραφείς:
Plata, E
Viniou, N
Abazis, D
Konstantopoulos, K and
Troungos, C
Vaiopoulos, G
Meletis, J
Kittas, C
Pangalos,
C
Yataganas, X
Περιοδικό:
CANCER GENETICS AND CYTOGENETICS
Εκδότης:
EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
DOI:
10.1016/S0165-4608(98)00012-0
