Τίτλος:
Could cisplatin as a front-line treatment in childhood non-Hodgkin's
lymphoma be a promising therapy?
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Non-Hodgkin’s lymphomas (NHL) were often erroneously diagnosed as other
malignancies and treated accordingly. In this study cisplatin combined
with vincristine, cyclophosphamide, and Adriamycin was weal incidentally
as a front-line treatment in seven children with NHL, because the
initial histologic diagnosis was that of a sarcoma. After reevaluation
three patients had Ki-1 anaplastic large cell lymphoma of T-cell origin,
two abdominal B-cell diffuse high-grade NHL, one mediastinal diffuse
large B-cell lymphoma, and one B-cell lymphoma in the stomach. They
received at least two courses of cisplatin combined regimen and
continued with other protocol for NHL. All patients showed an extremely:
good response from the first course of therapy and the masses vanished
completely. They were followed up for a mean time of 29.5 months and are
all in complete remission. The data indicate that cisplatin is active
against NHL and might be a promising alternative front-like therapy.
Συγγραφείς:
Papadopoulou, AL
Moschovi, M
Panagopoulou-Cristaki, M and
Anagnostou-Keramida, D
Van Vliet-Constantinidou, C
Botsonis, A
and Tsangaris, GT
Tzortzatou-Stathopoulou, F
Περιοδικό:
Pediatric Hematology and Oncology
Εκδότης:
Taylor and Francis Inc.
Λέξεις-κλειδιά:
childhood; cisplatin; front-line treatment; Ki-1 lymphoma; non-Hodgkin
‘s lymphoma
DOI:
10.1080/088800199277173
