Περίληψη:
Patients with pathologically increased daytime sleepiness and fatigue
have elevated levels of circulating interleukin-6 (IL-6). The latter is
an inflammatory cytokine, which causes sickness manifestations,
including somnolence and fatigue, and activation of the hy
pothalamic-pituitary-adrenal axis. In this study, we examined: 1) the
relation between serial measurements of plasma IL-6 and quantity and
depth of sleep, evaluated by polysomnography; and 2) the effects of
sleep deprivation on the nyctohemeral pattern of IL-6 secretion. Eight
healthy young male volunteers were sampled for 24 h twice, at the
baseline state, after a normal night’s sleep and after total overnight
sleep deprivation. At the baseline state, IL-6 was secreted in a
biphasic circadian pattern with two nadirs at 0800 and 2100 and two
zeniths at 1900 and 0500 (P < 0.01). The baseline amount of sleep
correlated negatively with the overall daytime secretion of the cytokine
(P < 0.05). Also, depth of sleep at baseline correlated negatively with
the postdeprivation increase of daytime secretion of IL-6 (P < 0.05).
Sleep deprivation changed the temporal pattern of circadian IL-6
secretion but not the overall amount. Indeed, during the postdeprivation
period, the mean daytime (0800-2200 h) levels of IL-6 were significantly
higher (P < 0.05), whereas the nighttime (2200-0600 h) levels were lower
than the predeprivation values. Thus, sleep-deprived subjects had
daytime oversecretion and nighttime undersecretion of IL-6; the former
might be responsible for their daylong somnolence and fatigue, the
latter for the better quality (depth) of their sleep. These data suggest
that a good night’s sleep is associated with decreased daytime secretion
of IL-6 and a good sense of wellbeing and that good sleep is associated
with decreased exposure of tissues to the proinflammatory and
potentially detrimental actions of IL-6. Sleep deprivation increases
daytime IL-6 and causes somnolence and fatigue during the next day,
whereas postdeprivation decreases nighttime IL-6 and is associated with
deeper sleep.
Συγγραφείς:
Vgontzas, AN
Papanicolaou, DA
Bixler, EO
Lotsikas, A and
Zachman, K
Kales, A
Prolo, P
Wong, ML
Licinio, J and
Gold, PW
Hermida, RC
Mastorakos, G
Chrousos, GP
